The promiscuous nature of drugs revealed

12 May The promiscuous nature of drugs revealed

The pharmacological activities of a drug can only be understood if its interactions with cellular components and its effects are comprehensively characterized. PhD student Piero Giansanti of the Biomolecular Mass Spectrometry and Proteomics Group at Utrecht University, in collaboration with research teams at the CeMM in Vienna, used mass spectrometry-based chemical proteomics and quantitative phosphoproteomics to characterize the all-inclusive action of tyrosine kinase inhibitors in cancer cells. Their work represents a multiplexed view on the promiscuous action of certain tyrosine kinase inhibitors in the treatment of epidermoid carcinoma. Their approach can contribute towards optimization of new drug molecules and management of side effects, ultimately leading to a more rational approach to skin cancer therapy.

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Evaluating the promiscuous nature of tyrosine kinase inhibitors assessed in epidermoid carcinoma cells by both chemical- and phosphoproteomics.
Giansanti, P., Preisinger, C., Huber, K., Gridling, M., Superti-Furga, G., Bennett, K.L., Heck, A.J.R.
ACS Chem Biol. 2014 May 7.