Nature Chemistry: Single particle native mass spectrometry

12 Mar Nature Chemistry: Single particle native mass spectrometry

To further explore the boundaries of single particle native mass spectrometry using charge detection on an Orbitrap Tobias Wörner Utrecht University tracked the flight paths of individual virus particles for several kilometers and observed that their trajectories are remarkably stable. This in-depth analysis of the behavior of individual ions within the Orbitrap analyzer allowed us to improve further Orbitrap-based CDMS, especially for megadalton macromolecular assemblies. As CDMS has unique applications in research areas such as structural biology, nanomaterials, fibers, vesicles, vaccines and human gene therapy (e.g. AAV gene delivery vectors) these improvements are expected to have substantial impact. Great collaboration with Alexander Makarov Thermo Fisher Scientific. The article appeared in Nature Chemistry and is now available online  https://lnkd.in/eWYTs_Cr or as a PDF via https://lnkd.in/ePVPqYiw.